Celladon is a privately held biotechnology company founded with the goal of becoming the leader in developing molecular therapies for the treatment of heart failure. Our products target the key enzyme deficiency in advanced heart failure, SERCA2a, which regulates calcium cycling and contractility in heart muscle cells. Our initial product candidate, MYDICAR®, delivers the gene for the SERCA2a enzyme.   The Phase 2 CUPID clinical trial shows sustained improvement at one year in cardiac function parameters and quality of life. Celladon also develops small molecule activators of SERCA2a for acute heart failure.

More than 670,000 new cases of heart failure will be diagnosed in 2010 and that number increases yearly. Without a breakthrough in treatment, 70 percent of patients will die within 10 years and 50 percent will die within five years. This year alone, the economic burden of heart failure will be $39.2 billion¹. Celladon’s products could dramatically lower the cost of care, improve the prognosis for heart failure and provide a better quality of life for patients in the terminal stages of the disease.

Our management team, board of directors and scientific advisors is comprised of industry recognized professionals who possess broad scientific knowledge in cardiovascular disease and extensive experience building biotechnology companies and managing drug development through clinical trials to FDA approval.

Celladon Corporation is based in La Jolla, California. Current investors include Enterprise Partners Venture Capital, Venrock Associates, and Johnson & Johnson Development Corporation.

¹  http://www.cdc.gov/dhdsp/library/pdfs/fs_heart_failure.pdf